Optimmune (0.2% Cyclosporine) Ophthalmic Ointment


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Optimmune is an eye ointment that contains cyclosporine. It is used for the management of chronic keratoconjunctivitis sicca (KCS or dry eye) and chronic superficial keratitis (CSK). This preservative-free ointment reduces the chances of chemical irritation and secondary infection, and can be stored for 24 months without refrigeration.


Optimmune Ophthalmic Ointment is indicated for the treatment of chronic keratoconjunctivitis sicca (KCS or dry eye) in dogs.

Possible Side Effects

Please contact your veterinarian if the following adverse reactions occur: eye or eyelid inflammations or redness, the mild discomfort of the eye, transient hyperemia, mild hair loss, lid spasm and excessive rubbing.

Drug & Food Interactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a failure to completely control the condition, rather than a true "adverse reaction."

On rare occasion, Optimmune Ophthalmic Ointment may be associated with local irritation such as periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hypersensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days see your vet.


When switching to this medication from another therapeutic agent (e.g., frequent application of an artificial tear preparation), keep in mind that clinical effectiveness is not necessarily apparent immediately after initiation of this medication. Several days to a few weeks may be required before the clinical effects are of sufficient magnitude, such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation can result in rapid clinical relapse, which may be erroneously interpreted as an adverse reaction to the medication. It is recommended that in cases of preexisting viral or fungal ocular infections, this medication is delayed until the infection has been successfully treated.

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Active Ingredient: Cyclosporine 2 Mg, USP.

Inactive Ingredients: Petrolatum, USP; Corn Oil, NF; Petrolatum and Lanolin Alcohol.

Recommended Dosage

A 1/4 inch strip is to be administered every 12 hours to the affected eye(s). The ointment may be placed directly on the cornea or into the conjunctival sac.

Storage Instructions

Store between 36° - 77°F.


What is Optimmune Ophthalmic Ointment?

Optimmune Ophthalmic Ointment is an eye ointment that contains cyclosporine. It is used for the management of keratoconjunctivitis sicca (KCS or dry eye). May also be prescribed for the management of inflammation in another eye condition called chronic superficial keratitis (CSK).

What are the benefits of Optimmune Ophthalmic Ointment?

  • Treats dry eyes
  • Fast acting
  • Reduces inflammation and irritation
  • Easy to administer

How is this medication given?

Give Optimmune exactly as directed by your veterinarian. Optimmune is given directly to the eye.

How does this medication work?

Cyclosporine has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production.

What results can I expect?

It may take a few weeks to achieve a maximum effect. If there is not improvement or the condition worsens, contact your veterinarian.

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